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  2. FCEN
  3. FCEN - Facultad de Ciencias Exactas y Naturales. UBA
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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributor<div class="autor_fcen" id="2338">de la Fuente, V.</div>-
dc.contributor<div class="autor_fcen" id="3324">Freudenthal, R.</div>-
dc.contributor<div class="autor_fcen" id="7439">Romano, A.</div>-
dc.creator<div class="autor_fcen" id="2338">de la Fuente, V.</div>-
dc.creator<div class="autor_fcen" id="3324">Freudenthal, R.</div>-
dc.creator<div class="autor_fcen" id="7439">Romano, A.</div>-
dc.date.accessioned2018-05-04T22:02:26Z-
dc.date.accessioned2018-05-28T15:48:29Z-
dc.date.available2018-05-04T22:02:26Z-
dc.date.available2018-05-28T15:48:29Z-
dc.date.issued2011-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68494-
dc.descriptionIn fear conditioning, aversive stimuli are readily associated with contextual features. A brief reexposure to the training context causes fear memory reconsolidation, whereas a prolonged re exposure induces memory extinction. The regulation of hippocampal gene expression plays akey role in contextual memory consolidation and reconsolidation. However, the mechanisms that determine whether memory will reconsolidate or extinguish are not known. Here, we demonstrate opposing roles for two evolutionarily related transcription factors in the mouse hippocampus. We found that nuclear factor-KB (NF-kB) is required for fear memory reconsolidation. Conversely, calcineurin phosphatase inhibited NF-kB and induced nuclear factor of activated T-cells (NFAT) nuclear translocation in the transition between reconsolidation and extinction. Accordingly, the hippocampal inhibition of both calcineurin and NFAT independently impaired memory extinction, whereas inhibition of NF-kB enhanced memory extinction. These findings represent the first insight into the molecular mechanisms that determine memory reprocessing after retrieval, supporting a transcriptional switch that directs memory toward reconsolidation or extinction. The precise molecular characterization of postretrieval processes has potential importance to the development of therapeutic strategies for fear memory disorders. © 2011 the authors.-
dc.descriptionFil:de la Fuente, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.descriptionFil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.descriptionFil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourceJ. Neurosci. 2011;31(15):5562-5573-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_02706474_v31_n15_p5562_delaFuente.pdf-
dc.subjectcalcineurin-
dc.subjectimmunoglobulin enhancer binding protein-
dc.subjecttranscription factor NFAT-
dc.subjectamino acid sequence-
dc.subjectanimal experiment-
dc.subjectanimal tissue-
dc.subjectarticle-
dc.subjectcontrolled study-
dc.subjectDNA determination-
dc.subjectenzyme inhibition-
dc.subjectlong term memory-
dc.subjectmale-
dc.subjectmemory consolidation-
dc.subjectmolecular dynamics-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectprotein analysis-
dc.subjectprotein function-
dc.subjectreinforcement-
dc.subjecttranscription initiation-
dc.subjectAnimals-
dc.subjectBlotting, Western-
dc.subjectCalcineurin-
dc.subjectCell Nucleus-
dc.subjectConditioning, Operant-
dc.subjectCytosol-
dc.subjectData Interpretation, Statistical-
dc.subjectElectrophoretic Mobility Shift Assay-
dc.subjectExtinction, Psychological-
dc.subjectFear-
dc.subjectHippocampus-
dc.subjectMale-
dc.subjectMemory-
dc.subjectMental Recall-
dc.subjectMice-
dc.subjectMice, Inbred C57BL-
dc.subjectNF-kappa B-
dc.subjectNFATC Transcription Factors-
dc.subjectTranscription Factors-
dc.subjectTranslocation, Genetic-
dc.titleReconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
Aparece en las colecciones: FCEN - Facultad de Ciencias Exactas y Naturales. UBA

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