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  3. FCEN - Facultad de Ciencias Exactas y Naturales. UBA
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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributor<div class="autor_fcen" id="3921">González Inchauspe, C.</div>-
dc.contributorMartini, F.J.-
dc.contributorForsythe, I.D.-
dc.contributor<div class="autor_fcen" id="8730">Uchitel, O.D.</div>-
dc.creator<div class="autor_fcen" id="3921">González Inchauspe, C.</div>-
dc.creatorMartini, F.J.-
dc.creatorForsythe, I.D.-
dc.creator<div class="autor_fcen" id="8730">Uchitel, O.D.</div>-
dc.date.accessioned2018-05-04T22:03:42Z-
dc.date.accessioned2018-05-28T15:48:27Z-
dc.date.available2018-05-04T22:03:42Z-
dc.date.available2018-05-28T15:48:27Z-
dc.date.issued2004-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68489-
dc.descriptionCalcium channels of the P/Q subtype mediate transmitter release at the neuromuscular junction and at many central synapses, such as the calyx of Held. Transgenic mice in which α1A channels are ablated provide a powerful tool with which to test compensatory mechanisms at the synapse and to explore mechanisms of presynaptic regulation associated with expression of P/Q channels. Using the calyx of Held preparation from the knock-out (KO) mice, we show here that N-type channels functionally compensate for the absence of P/Q subunits at the calyx and evoke giant synaptic currents [approximately two-thirds of the magnitude of wild-type (WT) responses]. However, although evoked paired-pulse facilitation is prominent in WT, this facilitation is greatly diminished in the KO. In addition, direct recording of presynaptic calcium currents revealed that the major functional difference was the absence of calcium-dependent facilitation at the calyx in the P/Q KO animals. We conclude that one physiological function of P/Q channels is to provide additional facilitatory drive, so contributing to maintenance of transmission as vesicles are depleted during high throughput synaptic transmission.-
dc.descriptionFil:González Inchauspe, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.descriptionFil:Uchitel, O.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourceJ. Neurosci. 2004;24(46):10379-10383-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_02706474_v24_n46_p10379_GonzalezInchauspe.pdf-
dc.subjectCalcium currents-
dc.subjectCalyx of Held-
dc.subjectFacilitation-
dc.subjectKnock-out mice-
dc.subjectP/Q channels-
dc.subjectSynaptic transmission-
dc.subjectcalcium channel N type-
dc.subjectcalcium channel P type-
dc.subjectcalcium channel Q type-
dc.subjectcalcium ion-
dc.subjectanimal tissue-
dc.subjectarticle-
dc.subjectcalcium current-
dc.subjectchannel gating-
dc.subjectfacilitation-
dc.subjectknockout mouse-
dc.subjectmouse-
dc.subjectnerve cell plasticity-
dc.subjectnonhuman-
dc.subjectpresynaptic membrane-
dc.subjectpriority journal-
dc.subjectsynaptosome-
dc.subjecttransgenic mouse-
dc.subjectAnimals-
dc.subjectBrain Stem-
dc.subjectCalcium-
dc.subjectCalcium Channels, N-Type-
dc.subjectCalcium Channels, P-Type-
dc.subjectCalcium Channels, Q-Type-
dc.subjectEvoked Potentials-
dc.subjectMice-
dc.subjectMice, Knockout-
dc.subjectNeuronal Plasticity-
dc.subjectPresynaptic Terminals-
dc.subjectProtein Subunits-
dc.subjectSynapses-
dc.subjectSynaptic Transmission-
dc.titleFunctional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
Aparece en las colecciones: FCEN - Facultad de Ciencias Exactas y Naturales. UBA

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